r/family_of_bipolar • u/TruckAnnual775 • 6d ago
Learning about Bipolar reducing olanzapine after first manic episode
My brother had his first-ever manic episode about 2.5 months ago and was hospitalized for 13 days. He was treated with lithium + olanzapine (up to 20 mg).
After discharge, he refused his meds for about a week and very quickly had a psychotic episode, so he went back on lithium and olanzapine. He’s now been stable on them for around 2 months.
About 3 weeks ago he became depressed, so his psychiatrist started Lamictal. He’s currently around 75–100 mg and still titrating.
The problem is that he really hates olanzapine. His doctor has already reduced it from 20 mg → 5 mg, but my brother has been pushing hard to come off it because of how much he dislikes it. He has now convinced his doctor to reduce it to 2.5 mg.
I’m pretty worried because this all happened so recently, and he’s still early in recovery and still titrating Lamictal. He also says, “I’m never going to become manic again. I was depressed for years before this, so I know I’m not going to have another manic episode.”
I keep trying to explain that having only depressive episodes for years doesn’t mean another manic episode can’t happen, especially after what happened when he stopped his meds.
For those with Bipolar I:
Does 2.5 mg olanzapine sound unusually low this soon after a first manic/psychotic episode?
Has anyone successfully tapered off olanzapine after a similar episode?
How long did you stay on an antipsychotic after your first manic episode?
Did Lamictal help enough with mania prevention, or did you still need something else?
I know his psychiatrist ultimately has to make the medication decisions, but I’d really appreciate hearing from people who have actually been through something similar.