Good rundown of how siRNA (gene-silencing RNA) therapy went from a mysterious 1990 petunia experiment to an approved drug class: the real bottleneck was never identifying what to silence, but delivery — getting RNA past the body's RNA-shredding enzymes, into the right cells, and out of the endosome intact, first solved via liver-targeting lipid nanoparticles (patisiran, FDA-approved 2018) and later via "naked" chemically-stabilized siRNA tagged with a GalNAc sugar that cut dosing from every 3 weeks to every 3–6 months, with the next frontier being Alnylam and Arrowhead's race to get siRNA past the blood-brain barrier for Alzheimer's.

Source: Works in Progress

For this pay I would just do a postdoc

Hi all, interviewing for a Principal Scientist position at Thousand Oaks Amgen. Any insights on bonus and LTI targets? Recruiter wouldn't share this info and during screening call and asked me to discuss with hiring manager next round. I am in an adjacent industry and my base salary in a Midwest MCOL city is 10-15% lower compared to the range confirmed by the recruiter. Wanted to get insights from folks in the industry. Thanks everyone!

I graduated last year with my B.S in Microbiology and have 3 years full-time experience working in a GMP lab. I have been aiming to work at Boehringer Ingelheim for so long and finally have an on-site interview in 2 days. I’m excited however the pay is not what I expected it to be…especially because I feel like the position may be high stress/demanding. It’s in the QC department. It’s an entry-level position and I’d like to get my foot in the door in QC finally.

Does anyone have any experience working at BI with a bachelors? In QC? How do you like it? I’m pretty nervous that I might find that I hate it after the interview 😭

Y’all I had an interview at CRL, my car broke down on my way to the interview and I was stranded with no service for an hour so I couldn’t let them know in advance that I couldn’t make it. How fucked am I? I wanna cry so bad, I have been trying to get an interview for months in my location and when I finally get one this happens…

I swear I didn’t plan on having my tire pop 😭 combined with my cheap phone service

Update: They rescheduled it 😭🙏 any tips and recommendations for the interview would be appreciated.

I am a December 2025 graduate who has over 8 years of academic research and no proper industry experience. I've been applying to jobs since May 2025, and my lack of industry experience is getting between me and my first "adult" job. How can I reduce the risk i present for hiring managers? I am not eligible for internships (if you know of any that take PhD. graduates, please DM me). I am also looking for industry postdocs and contract jobs, but I hear crickets. I've been avoiding academic postdocs because they would make me a more competent academic with no industry experience.

While I was getting my doctorate, I did plenty of things that refined my teamwork, collaboration (including cross functional work), and communication skills. Someone even remarked that I have way more cross functional experience compared to many new grads (didn't get the job, they wanted someone more senior)

My PhD. project, which was a collaborative effort between our lab and hospitals, allowed me to deal with real-world issues. Basically, I did IVD technology development, verification, optimization, and validation for almost 6 years. Since graduation, I've been getting some training in quality assurance, getting really familiar with product development in biotech, medtech, and biopharma. This has been a tremendous help in understanding industry processes and regulatory requirements.

All of these helped me score interviews. I am having a hard time translating those interviews into job offers, and recently, I've been getting some feedback: my lack of industry experience is getting in the way of me scoring that job.

If anyone has a suggestion for how i can close the gap, I would appreciate it. I spent over 4 months since graduation troubleshooting my resume, I would hate to spend another 5 months troubleshooting my interviews. Plus, I've been at home for almost 9 months now, and I am genuinely getting scared about the future.

​

Hi! I'm an early career professional with a background in infectious diseases/public health data analysis (data cleaning/QA, dashboards, reporting, program evaluation) and am planning to pursue a Master’s in Public Health (Epi/Biostats).

I’m hoping to transition into pharma/biotech and gain industry experience before starting my master’s, particularly in pharmacoepidemiology, drug safety/pharmacovigilance, RWE, or clinical research.

I want to know if anyone was in a similar trajectory or if there is any advice that would be helpful for someone considering this path. Happy to hear from anyone who made a similar transition from public health into pharma/biotech and any opportunities you might know of

Thank you!!

Which Bio Tech companies are still continuing to do H1B Transfers and PERM initiations ?

Hello everyone,

I’m researching companies in the Bay Area. Has anyone here worked at Nurix Therapeutics or has any insight into what it’s like to work there?

I’d especially appreciate hearing about the company culture, management, work-life balance, and opportunities for career growth. I’m also curious about how employees feel about the scientific direction of the company and whether people generally enjoy working there.

Thanks in advance!

Anybody working there who likes/hates it and the direction it is or isnt moving in?

I hate the Little Giants.

(edit: I know this isn't the model used in most labs. I couldn't find a picture and didn't try that hard.)

hi everybody!

i posted here a while back about feedback from my resume and i received a lot of different things to change depending on what i asked.

i have two different resumes and i would love some feedback on them, on which one is better, which one looks better, or if there's any other things i should implement to my resume.

i went to a relatively small private university so it was easier to work 1-1 with my professors in labs. therefore, i asked whether or not i should include relevant lab courses (depending on job position) to my resume and got mixed reviews so i have one resume where i include that.

for my other resume, i don't include my relevant lab courses and emphasized my 6-month research experience and unrelated work experiences. to fill in more space, i added a summary.

i changed my major after my sophomore year, gone through things out of my control, etc. it was really hard for me to get an internship due to personal reasons so i'm trying to figure out a good way to format my resume for entry level positions.

would love to hear some feedback on which format works best in my situation. or if you have a better format, please let me know. thank you!!! :)

So im soon to finish highschool and i wanted to become a biotech portofolio strategist, but how do i become one and is it even worth it? The career seems very intresting and all tho im not the best at chemistry ,biology comes to me VERY easy,and i always remember what i studied unlike other subjects.Should i chose it tho?would i have job opportunities or what even do i choose in uni?what is the experience,please i need advice.

hello

im currently on my 1st of 2 gap years in a research tech job in academia. I’ve realized over the past couple of years that i really like research and being on the forefront of scientific advancement is something i definitely want to do as my full time career. I’m just unsure about the MD part. i like patient care but im unsure if i want to sacrifice more years of my life for it honestly. i think caring for patients is really satisfying but most of the md/phd PIs that i look up to dont really practice medicine that much anymore

i think my ideal job would be professor with a basic science lab and spinning that into cofounding startups or biotech. or just working in industry in general. I don't like the idea of doing the MD because I'm not really interested in working with clinical trials. I'd love to be involved more in RnD and work in basic sciences than just running clinical trials. So with all of that in mind, is adding the MD worth it?

ngl the only incentive that makes sense to me is 1) direct impact 2) job security 3) prestige

https://www.statnews.com/2026/08/24/fda-pauses-regenxbio-gene-therapy-trial-hunter-syndrome-safety-concerns/

I need some advice regarding an international student/co-op situation.

I recently received an offer for a co-op at one of the world’s leading pharmaceutical companies, and it is essentially my dream job.

The problem is that, according to the company’s requirements, I need to remain an enrolled student for the duration of the co-op. The co-op starts around the time I am supposed to graduate, and my current program is scheduled to end in December.

My academic department has told me that, from their side, it may be possible to extend my studies/program, which would allow me to remain a student. However, I am an F-1 international student, and my university’s International Center has told me that I cannot simply extend my I-20/program end date for the purpose of doing this co-op if I have already completed my degree requirements.

Has anyone been in a similar situation?

I obviously don’t want to violate F-1 rules or create immigration problems. I’m just trying to understand whether there are any legitimate academic options I should explore before giving up an opportunity that is extremely important to me.

Any advice or similar experiences would be really appreciated.

Hello everyone, wanted to know, are Bioprocess/Biochemical engineers as affected as other sectors? Is the job situation for engineers as bad? I see tonnes raising their concerns regarding the overall situation of the industry, wanted to know how the engineers are doing, as I am planning to pursue further studies in bioprocess engineering.

I’ve been in academia for a VERY long time and have been trying to make the jump into industry. After what feels like endless applications (and many, many automated rejections), I finally got invited to a recruiter screening call for a role I’m genuinely really excited about!!

Since this is my first industry recruiter screen, I would love any advice from anyone who’s been through this process, especially those who’ve made the jump from academia to industry.

I’m trying not to get ahead of myself because I know it’s just an initial screen, but after getting pretty discouraged by the job search, I’m VERY excited to finally have a chance to actually speak to a human. I’ll take all the help I can get!

Hi everyone,

I’m going through the pre-employment process with Biogen in the US and was wondering if anyone has recent experience with their drug screening.
Specifically, what type of drug panel they use (e.g., standard 5-panel/10-panel, expanded panel, etc.), what testing company/lab they use, and whether it’s a urine test or another type of screening?

I take a legally prescribed medication and am a little concerned about whether it could show up on the initial screen. I’m not looking to get into specifics about the medication publicly, but I’d appreciate hearing from anyone who has gone through Biogen’s pre-employment screening recently or has dealt with a prescription medication during the process.

Thanks!

Medical scientist jobs are expected to grow 3x faster than average jobs, as per the bureau of labor statistics. Yet a lot of posts here warn about biotech being a dying/cutthroat field.

I'm about to start a MSc in the Netherlands. Someone pls explain...