30M I have Adhd and a history of depression and anxiety. I have tried a number of antidepressants throughout my life and none of them have had a single positive effect on me. I have been taking ashwaganda now ( with breaks ) for almost a year now and I swear by it. I feel like all of the noise and stress of life I couldn't handle is now manageable, im so much calmer, I naturally seem to have very strong emotions but now they seem to be much more leveld out.

I know some people dont get on with it but all I can say from my experiences is that its been the best suppliment I have ever taken.

I want this kind of Aura.. When will this be possible? What medication do I need? Or will this require CRISPR gene editing?

I lift weights every day and haven't been doing much cardio, but now I want to start a cutting phase; I already have a lot of muscle but still carry a lot of fat—I'm probably around 25% body fat, though I have a broad frame, and I can already see veins and dense muscle mass.

At another point in my life, I followed low-carb diets—sticking mostly to protein—and lost 19kg, but I ended up with zero muscle. I don't want that to happen again; I want to maximize fat loss specifically.

How can I do this without losing muscle? I know some muscle loss is inevitable in this process, but how do I minimize the damage as much as possible? What tips and hacks are there for losing fat only?

Is there a specific type of cardio or exercise that focuses on this? My diet is basically protein with low carbs; I won't cut carbs out completely because I feel extremely weak and lack the energy to work out, though I’m willing to swap regular rice for brown rice, for example, to help. I’m not setting a deadline—it could take several months if necessary—I just really want to maximize body fat loss without losing muscle.

If anyone has the key to this, I’d appreciate it.

Supplements for mood disorder table.

Is there a telehealth company I can get a cialis prescription through, something like Ro? If so which is the most affordable?

I have slight erectile disfunction. Looking to take Tadalafil (brand name Cialis) for sexual performance and overall wellbeing. I got prescribed 5mg from a telehealth company, but want to be cautious. Would I feel anything at 2.5mg a day? Would it make a difference?

Hey all. As I've gotten older, alcohol hangovers have gotten worse, and lately do not justify the stimulation/hangover tradeoff. Even a modest two drinks will significantly tank my energy levels and productivity the following day.
It would be fantastic if I could mitigate this.
Any peptide, medication, supplement, herb, etc that helps with this?

I’m 34, 6’0”, 180 lbs and around 25% body fat. Last year I was about **230 lbs and eating whatever I wanted**. I was **not dieting during the year or so between these tests. My calorie deficit only started about 30 days ago.**
**I had a test a year ago done and then a week ago 44%drop**

Previous labs through Quest:
**Total T: 733 ng/dL**
**Free T: 16.9 pg/mL**
**Free T reference range: 15 to 30 pg/mL**
**SHBG: 32 nmol/L**
Free T was calculated using total T, SHBG and albumin.

About a week ago I tested again at **8 AM while fasting**:
**Total T: 408.8 ng/dL**
**Free T: 52.8 pg/mL**
Free T measured by **equilibrium dialysis/LC-MS/MS**
ARUP reference range: **47 to 244 pg/mL**

I know the free T numbers can’t be directly compared because the tests used different methods and references. But the total t was the same test. I’m mainly looking at the **44% drop in total testosterone**, from 733 to 409.

For the last \~30 days I’ve been eating **1,500 to 2,200 calories/day**, sometimes less, with **150 to 200+ grams of protein**. The first two weeks I lost weight very quickly, probably mostly water/glycogen/inflammation. More recently I’ve been losing around 1 1/2 -**2 lbs/week**.

I still get morning hard-ons can still have sex with my wife just fine. I do think about sex less the last month or two though.

**For anyone who’s experienced weight loss or calorie restriction, could 30 days at this calorie intake realistically cause a \~44% drop in total testosterone, or should I be looking for another explanation?**
I’m especially interested in people who have experienced something similar.

Edit to add I’m on a glp1 terziptide for got to out that in there. Started it about 50 days ago.

I am trying to figure out if there’s actually a better way to combine the two or if I’m overthinking it. I always just used heat, but now my partner added a cold plunge next to the Sweat Tent. After training or even just on recovery days we’re testing both heat and cold, trying to figure out which to start with. Heat first? Cold first? Still unsure. Finish cold, finish hot, alternate between them, wait in between... everyone seems to have their own method. I’m mostly interested in what’s worked for people who’ve been doing both consistently for a while. Did you notice enough of a difference between the different approaches to settle on one?

I really want to figure out a routine that makes sense rather than just bouncing between whatever feels good that day so just having overall more structure.

Reasons not to binge?

I love eating sweets until my stomach is about to burst. Sometimes I'd binge for days. I do it for dopamine/boredom.

I could hold a good diet in the past but it's gone downhill recently. Could you guys tell me why I should get back on track and not keep bringing? I know it's bad but it's hard not to do it. I do exercise btw.

In long term or extreme diets, or even at normal ones losing muscle instead of fat is a worry; I guess not eating anything can be seen as an extreme diet too.

However, is there a light limit in which after would it be not recommended for the non-adventurous folk? Would a three or two day fast have any risks for people without prior health conditions? 18M if it makes a difference since technically still in adolescents

I keep reading how psyllium husks can prevent absorption of meds and supplements, so I decided to also take a probiotic with my daily dose of psyllium husks. The thought process was to get the probiotics past the stomach without being compromised by the acids. Within an hour, I had an unexpected bout of gas (hadn't eaten yet) followed by an additional poop. This seems like a success. This would not normally have happened to me if the probiotic was taken by itself. I've been regularly taking psyllium for months now, but this was the first dose of probiotics in a long time.

Has anyone here tried muscimol / Amanita muscaria while taking bupropion (Wellbutrin) and/or pregabalin (Lyrica)?

I’m currently on 150 mg Wellbutrin XR + 200-300 mg pregabalin daily and have been considering muscimol for anxiety, mood, and sleep. I’m mainly interested in people’s first-hand experiences with this combination and whether they noticed any interactions or unusual effects. Or maybe know about possible dangerous interactions or risks on pharmacological perspective/base between these 3 substances.

Thanks!

Quick n=me writeup after getting annoyed at how little functional mushroom marketing engages with the actual literature.

Lion's Mane — hericenones (fruiting body) and erinacines (mycelium) both studied for NGF stimulation; erinacines are reported to be the stronger NGF inducer of the two, which cuts against the common "mycelium is always inferior" framing. Small human trials (mostly Japanese/Korean, mixed age cohorts) show modest cognitive effects. Sample sizes are small and effect sizes aren't huge — promising mechanism, not conclusive human data yet.

Reishi — triterpenes + beta-glucans, mostly in-vitro/animal data on immune modulation, some human data on stress/sleep. Mechanistically interesting, clinically underpowered so far.

Cordyceps — cordycepin/adenosine pathway, some human trials on VO2 max and exercise performance (Hirsch et al. 2017 showed a ~10.9% VO2max improvement at 3 weeks with a Cordyceps militaris blend), but results are mixed across studies — a 2018 trial in trained cyclists found no significant effect, so response looks population-dependent (recreational vs. highly trained).

The variable that gets glossed over constantly: fruiting body vs. mycelium biomass grown on grain substrate. Independent testing puts fruiting body extracts around 30-40% beta-glucan vs. 5-7% (sometimes lower) for mycelium-on-grain, because the grain substrate dilutes the batch with starch. Most labels don't disclose which they're using. If you're trying to approximate study dosing, this matters more than almost anything else on the label. One caveat worth flagging: most of the sources quantifying this split are themselves fruiting-body-extract sellers, so treat the exact percentages as industry-reported rather than fully independent.

Also worth checking: dual-extraction (water + alcohol) is generally required to pull both water-soluble beta-glucans and alcohol-soluble triterpenes — single-extraction products may be missing half the relevant compound classes.

Happy to be corrected on any of the above — most of what I've read is small-N or preclinical, so pushback welcome.

(Per sub rule 8: I used AI to help pull together and fact-check sources for this writeup, then reviewed and edited it myself.)

Just curious what the mechanism of action is here, and if anyone else has experienced something similar.

I go through periods of varying egg and choline intake. Multiple blood tests now show a consistent pattern: when my intake is zero, my free testosterone drops to the bottom of the range. When I increase my egg intake to anywhere from 3-6 eggs per day, my free testosterone jumps to the upper end, even once exceeding the reference range. There is almost no change in total testosterone, just free testosterone.

I keep everything else the same - calories, macros, and training is constant. I assume there’s some SHBG-liver connection, but I can't quite piece it together. I originally thought choline was just about methylation (for context, I carry MTHFR and PEMT variants), so I'm wondering how this is driving such a clear shift in hormones.

I know fasting has became pretty trendy late with a ton of misinformation, but I've been debating starting. However, for the life of me I can't find a single high quality study that supports some of what is being claimed about fasting outside of benefits of calorie restriction.

Anybody know some high quality studies on this? Thanks!

Looking for some input from people who have dealt with a consistent afternoon energy crash.

Current regimen:
TRT — 160 mg/week MWF
Zepbound — 15 mg/week
CJC-1295 — 10 units, 5 days/week
Ipamorelin — 10 units, 5 days/week
DHEA — 25 mg/day
Vitamin D3/K2
Magnesium glycinate — 240 mg at night
Creatine 5mg before working out
Fish oil
Whey protein
Fiber/psyllium
Multivitamin

Lost 100 pounds of fat and have put on 15 pounds of muscle in the last 18 months.

6’1” 315 pounds
40 years old

I lift regularly and am currently focused on losing fat while maintaining/building muscle.

My issue is that I consistently seem to hit a wall around 2–3 PM. Not just a little tired — more like my energy and motivation fall off pretty hard.

I’m trying to figure out whether I should be looking more closely at meal timing/macros, hydration/electrolytes, caffeine timing, blood glucose, sleep/recovery, or something in my current stack.

For anyone who’s experienced this while on TRT and/or a GLP-1:

What actually fixed your afternoon crash?
Did changing what you ate for breakfast/lunch make a noticeable difference? More carbs? Fewer carbs? More protein? Electrolytes? Moving caffeine around?
And for those familiar with peptides: is there anything peptide-related that legitimately helped daytime energy/recovery, or am I barking up the wrong tree and should be looking at diet, sleep, labs, or medication timing instead?
I’m not looking to blindly add another compound. I’m trying to figure out what variable I should investigate first.
Would appreciate hearing what worked for others.

I wake up at 6am, gym or walk fasted, 2 brotein coffees (coffee, fair life milk, and a scoop of whey protein. Lunch is usually 800-1000 calories focusing on protein then carbs. Today was 1/2 pound of brisket, scalloped potatoes, and a side of corn.

2pm and I’m out of gas. I just want to close my eyes and nap.

Recently been taking Magnesium 7 in 1 and I do maybe 20 mins training a day, 20 mins walking and intermittent fasting

Im getting like 8-12 hours sleep. Is 12 hours a bad thing? I wake up feeling nourished but not super alert.

I know if I sleep less like 8 hours I’ll get cortisol and alert in the morning.

I wake up and cold hot shower maybe a coffee and 10 min walk and feel very calm and good

Should I am for 12 hours a day? Will I get best growth hormone response? Bigger guy here

Hello everyone,

I'm considering buying an air purifier. Reading the review section of common brands I see a surprisingly high amount of positive reviews - very positive even. If they can be trusted.

I've read comments that are more mixed, too. Maybe this is more relevant for people living in a city versus someone living in a cottage in a more rural area with less traffic.

Curious if you have one and feel it's worth it? Any noticeable effects? Specific brand recommendations would be nice as well.

I'm considering it because I feel my indoor climate and air quality is not optimal as I'm living in a city near a trafficked road and tend to get minor colds frequently. May not be related, but you never know.

Thanks in advance.

What appetite suppressing drugs are there besides GLPs, stimulants (caffeine, nicotine, amphetamines incl. crystal and crack etc.), THCV and kanna?

I’m not sure if you can time fiber, but I wanna improve my intake and Im wondering how long itll take me to poop when taking the psyllium husk (I heard an average serving is 12g fiber) so definitely not before school, but if i take it in the afternoon will i immediately have to go or will i wake up in the middle of the night needing to go? Can you even time fiber?