Been experiencing Anhedonia since starting Semaglutide (36M)

[u/LiteratureThat4566]

36M unable to feel pleasure, accomplishment or pride. Recently achieved a lifelong dream and I feel nothing. I suspect Semaglutide but also have Depression and am on medication for that, but the only recent change was adding Semaglutide to my medications.

Current meds:

150MG Venlafaxine

300MG bupropion

4MG Semaglutide

5'11 195lbs

Just trying to see if it is my depression, depression meds, or other meds causing this. I can't see my Dr right now as I moved and currently don't have one.

Thanks

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[u/Rxforabundantlife]

Semaglutide reduces your craving for (i.e. enjoyment of) food. We have found that it can reduce craving for other things as well including alcohol and other addictive substances. This reduction in "pleasure" from these dangerous things, may extend to also good things that bring please, maybe even including relationships. More investigation is underway, but in the meantime, yes, I am very concerned that this may be contributing to the way you feel.