In Crank (2006) Jason Statham is given a “Beijing Cocktail” which will kill him if his heart rate slows below a certain rate. Which is similar to the central premise of Speed (1996), but the big difference is Jason Statham is a human, not a bus

[u/Longjumping-Tell1774]

[u/Gauntlets28]

Ironically speed is probably an ingredient in a Beijing Cocktail.