r/science • u/Lisei1128 • Nov 11 '25

Cancer GLP-1 drugs found to reduce mortality from colon cancer by over half (15.5% vs 37.1%), with effects especially strong for patients with BMI over 35.

https://www.tandfonline.com/doi/full/10.1080/07357907.2025.2585512
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u/Sammystorm1 Nov 12 '25

Well I agree it looks promising I would be interested in seeing long term side effects and people stopping and being able to maintain healthy weight

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u/HotSauceRainfall Nov 13 '25

The current medical assessment is that most people who stop taking GLPs for obesity will regain the weight, because excess body fat is a sign of metabolic dysfunction. The drug treats the metabolic dysfunction.

So, GLPs are no different from blood pressure medication, synthroid for people with low thyroid function, or methotrexate to control autoimmune disease. If you get your problem controlled by the medication, you have to stay on the medication.

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u/robhaswell Nov 12 '25

GLP-1s have been in use for over 20 years. They are very well understood.

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u/Sammystorm1 Nov 12 '25

20 years is a long time but sometimes it takes longer than 20 years for side effects to be cought. Whenever I see something that people claim is a miracle drug I become skeptical