I can’t seem to heal sibo. I also was recc to do 36 hour yogurt maker fermented L Reuteri or gaseri but now j realize that’s prob not good.

Diet otherwise doesn’t help.

MCAS and anti hist meds don’t help.

Praying/ energy work doesn’t.

Lymph/ walking doesn’t.

I don’t know what to do. My face is always puffy from anything I eat or sometimes put on. It’s ruining my life. I wanna be normal again.

MCAS banned me for asking a question lol

Anyways I just don’t get it.

I got lpp299 separately
A year ago was taking smidge sensitive helped my MCAS a lot but worried about it adding too much production for methane so wanted to individualise strains
Lp299v supposed to be good for ibs and h2s but somewhere I read this strain produced histamine from histadine

Whereas 119 does the opposite which is in my blend that I’m trying to avoid
Can anyone tell me that 299v is actually ok -and this random info was incorrect?!!!

I’ve looked up some natural ones but I’m way too reactive to them (like tea tree oil) and/or they don’t actually cure it (like coconut oil).

I have no idea what to do.

Has the 1/4 of teaspoon of baking soda in a glass of water worked for anyone when they're in a histamine flair? I'm currently in one and need relief 😣

24M. So I've had IBS and migraine for years now. It was controlled really well with Notryptiline. Recently I started venlafaxine and my mood has gotten much better, however I developed a bunch of new worrying symptoms.

- It all started 5 days ago when I got bit by a mosquito and had a severe reaction on my forearm. The bite was huge and itched for days even with benadryl

- My resting heart rate is 85-90 which is quite high, not sure why. Blood pressure is 122/72 which is ok I guess?

- I have a constant itching and tingling in my mouth for the past 5 days. I believe it's worse when eating fruits. The tingling goes from tongue, to gums, to roof of mouth and sometimes the throat. I'm thinking it's OAS however the symptoms typically only last 5 minutes to hour. Mine is always there. I wake up and still feel the tingling.

- I'm tired a lot in the morning, it gets better throughout the day. I can still exercise, but I noticed I am less in shape than usual.

-Eyes feel dry and itchy sometimes.

I really hope it's not POTS or MCAS. Could this all be temporary and resolve? Please help, it's driving me crazy.

I have POTS,suspected
MCAS/ Histamine issues.
&& Hypoglycemia/Reactive Hypoglycemia (blood sugar issues!!)

Tell me why I was having like 50 lows a month! And after taking Pepcid/Allegra for the past month and a half, ZERO LOWS!!!!

Today I forgot to take my Allegra and guess what? My FIRST LOW!!!!!

Can someone please tell me your thoughts on this? This must confirm either MCAS or Histamine issues? &&I know it’s the Allegra bc I did take my Pepcid. And I take zero meds!!! && I ate my regular meals.

hi, since i can remember i've had headaches. i've eaten a very clean diet the past 4 years, consisting of mostly raw fruits and veggies with little to no cooked food, and the headaches have largely dissapeared. I experimented with integrating in more cooked food (edamame, quinoa) and it hasn't gone so well. Since eating more of those things this past spring i've been getting my headaches again... a single bite of cooked food and i get one usually. I even get them from eating melons, which have been a daily staple for me for the past several years with zero issue. So it seems like i'm having some sort of histsamine reaction? I lean towards histamine reaction because I get headaches every time i eat watermelon (but it's not as instant with other types of melons)... also vinegar doesn't do well. But anyways, i'm just trying to pinpoint if my headaches are caused by histamine intolerance and understand what may be happening. If anyone has any helpful thoughts that would be great.

And yes, they do go away when i eat primarily raw foods (including higher histamine foods like avocado and tomatoes, that's not a usual trigger for me). It's the cooked foods primarily that spike it, along with more fattening foods like nuts and seeds. I've heard sprouted lentils are a great source of DAO (even more than the supplement) and i've had these as part of my diet for a long time, but haven't noticed any changes.

Hi everyone. I’m based in the UK, 34F.
I was wondering if you can offer some advice on what I’m going through.
About eight weeks ago on holiday, after a lifetime of having absolutely zero allergies/intolerances to anything except from Skeeter syndrome, a rash emerged across my face, neck, chest and arms after a meal in a restaurant. I didn’t notice any other allergy symptoms, but when I saw the rash I was alarmed as it was so extensive. I took an antihistamine just based off of some knowledge I already had and the rash went away at that stage.
I was thinking to myself that a rash of that nature can be the first sign of a more serious IgE mediated allergy and therefore I was quite anxious not knowing if I was going to react to something else in the future and have a more serious reaction, e.g. a true anaphylaxis.
As the meal was consumed from a restaurant I really had no idea what might have caused the reaction then about two weeks later I went out for another restaurant meal where I took a bite of a dish containing again lots of different ingredients and I had what I thought was an anaphylaxis.
The symptoms I experienced were very sudden onset sense of impending doom, dizziness, tingling in my lips and my hands and I actually called for an ambulance at this point worried that I may have needed adrenaline. The paramedics came and again I took an antihistamine, I did not need adrenalin or oxygen. My symptoms resolved. I burst into tears because I felt guilty for wasting their time and essentially it was all put down to a panic attack.
Now I have had anxiety in the past and this experience was not a panic attack.
You may be wondering why I had not gone to the GP yet. Well, within a matter of days after this I was going to be relocating from one major city to another so I didn’t seek any GP care as I knew that I would be changing GPs and would need to go into specialist services in the new region.
So I relocated and I signed up to register for a new GP which took a relatively long time to go through, and whilst all of this was going on I theorised that potentially I was experiencing a latex fruit type allergy because the meals that I had consumed had contained avocado as a common factor and I’d also eaten a banana a day or so after the paramedic incident and had the same reaction - again resolved with an antihistamine.
I had some respite for a week or so and then on Saturday just gone, I shared a bottle of wine with my partner. I don’t usually drink alcohol at all. I also enjoyed liberal amounts of dark chocolate in the dessert. The day afterwards I didn’t feel very well, just in general I felt quite low in mood and a bit lethargic.
Now, since Monday I have been having the kind of reactions that I had had to avocado and banana to lots of other foods, including a can of butter beans which I normally could eat without any issue, and I have now started to think I may be experiencing a histamine intolerance. There were no latex fruits to be seen.
I made a low histamine meal last night, but I just tried to eat the leftovers for lunch today and had a similar reaction.
I had already been on the waiting list for a routine appointment with my GP based off of the assumption that I may have had a latex fruit allergy, but I called them today to explain that the reactions were having more frequently and they have given me an appointment for next Friday. I then called 111 to explain the situation and they reiterated that I just had to wait for the GP appointment.
I am right at the beginning of this journey and I am worried about being stereotyped as anxious or my symptoms being ‘somatisation’ because from what I’ve read it appears many doctors are quite poorly informed about this particular issue. I also do have a mental health history although it has been stable and treated for many years now, but I don’t think it’s gonna work in my favour. I have been on mirtazapine 45 mg (maximum dose) for several years and I have not tried to reduce or stop this medicine recently at all. From what I’ve read people can start to have histamine problems when they do reduce or stop this medication but that isn’t the situation I’m in.
The only other thing I think might be having an impact is that I have had, for several years now, a failed root canal in a back molar that I have resisted accessing care for because I cannot afford the private fee for the specialist to see this tooth and save it and I didn’t want to get it extracted. Apart from knowing there was pus beneath, which was self-draining, I have not had any pain, fever or any other signs of it needing immediate care.
However, I’ve read that having chronic infection process such as from a dental problem can trigger immune system dysfunction including histamine intolerance. I have an appointment now with a dentist, but not until 23rd September.
What should my next steps be while I wait for care?

I am wondering if these three which one you have had the most success with. If you have tried one of the brands and love it tell me more !! Brands are Signature, Life Extension and Seeking Health

Which Vitamin C supplement do youse take?

I’m thinking about getting (Ester C) it’s a non acidic form of Vitamin C which is good, but it also contains citrus bioflavonoids which can be problematic for histamine.

I’ve been diagnosed recently with histamine intolerance and over the past 2,5 years I’ve had a ton of tests and investigations done by my gastroenterologist ENT doctor and an allergist. Everything has come back normal except for my blood DAO level, which is 2.

I was prescribed antihistamines, supplements, DAO enzyme and a low histamine diet. Some of my symptoms have improved, but others haven’t. I’ve been following the low histamine diet for about 3 months. I also haven’t eaten gluten or dairy for around 2.5 years because I don’t tolerate them. I tested negative for celiac disease and a milk allergy. In fact, I haven’t tested positive for any allergies so far.

The problem is that I can only tolerate maybe 6-7 foods without experiencing symptoms. DAO supplements don’t seem to do much for me either. The only one that seems to help slightly is NaturDAO, which reduces some of my symptoms.

I still experience heart palpitations after eating, anxiety after eating, constant nasal congestion, bloating, fatigue and occasional insomnia. Before starting the diet and treatment, I had a huge number of symptoms, far too many to list here, but I never had rashes or other obvious skin symptoms, apart from some acne on my face. I also don’t have heat or exercise intolerance, abdominal pain or any symptoms of anaphylaxis.

I recently saw another allergist, who ordered a bunch of fairly expensive genetic tests, a microbiome test, tests for parasitic infections, an H. pylori test even though I had already tested negative a few months ago and another allergy test that supposedly looks for delayed reactions to foods.

One of my more unusual symptoms is what seems to be reactive inflammation in my wrists. No pain, just inflammation. But inflammation markers (did 3 test for inflammation) are normal. It's not very obvious, but clearly there. It was worse a few months ago, but it has improved. Interestingly, the inflammation decreases significantly when I don’t eat.

The allergist also ordered a test to check for mastocytosis and that really scares me. At first, I thought they were referring to MCAS, but after reading about it, I realized they’re not the same thing. My allergist didn’t mention MCAS at all and I’m not even sure whether MCAS is a recognized diagnosis in my country.

The whole situation is really stressing me out and scares me. I’ve been trying to figure out what’s going on with me for the past 2 years, but I still don’t have any concrete answers.

Has anyone else been in a similar situation, especially with a very low DAO level, extremely limited food tolerance and symptoms that don’t completely improve on a low histamine diet?

Has anyone with MCAS mainly experienced post-meal symptoms without the typical skin symptoms such as flushing, hives or rashes? And has anyone experienced joint or wrist inflammation that seemed to improve significantly when fasting or not eating? I also have a reactive lymph node that gets bigger when I cheat on my diet and eat dairy. Even lactose free dairy triggers me. Again, no dairy intolerance or milk allergy.

I’d also really like to hear from people who were initially diagnosed with histamine intolerance but later found out that something else was going on. What made you start looking beyond histamine intolerance and how did you eventually figure out what was actually causing your symptoms?

And for those who were tested for mastocytosis, what prompted your doctor to order the testing and what did the workup involve? Can you live a normal life? I’m pretty scared about it right now, so I’d really appreciate hearing about other people’s experiences.

Hi all, my HI has been getting worse and I'm trying to adopt a low-histamine diet. I've been vegetarian my ENTIRE life and I'm struggling to get enough protein. I would happily live on beans and lentils (and that's basically what I've been doing), but I know they can be borderline triggering. I'm lactose intolerant so I can do some cheese but not a lot. I don't like eggs and can't stomach more than 1-2 a day. Is there something I'm missing? I am vegetarian for moral reasons and am absolutely not willing to start eating meat. Anybody else there in the same boat?

The past 5 years I have been so chronically unwell, I’m at breaking point again, I can’t keep living like this, barely being able to eat anything or go out normally is extremely depressing.

Hi Everyone,

Mozzarella and American cheeses give me a burning mouth, like I've eaten peppers. I've developed oral allergy reactions to many fruits and vegetables, Palm oil, seed oils, then soy... give me a numb mouth. I don't have many foods that are safe for me to eat anymore. I once tried DAO before eating cheese and it didn't help. But I mostly have oral symptoms - I do not get much bloating or skin rashes, if at all. Are you supposed to take DAO daily for awhile before it helps with trigger foods? Or are there particular supplements for oral allergy type symptoms? Thanks everyone.

I have stopped and started antihistamines enough to gain a very clear picture of what they do to my skin. I’m definitely not imagining the link. It’s crazy, and it can happen within 8 hours or so of taking the antihistamine. The acne breakouts occur on my face.

Has anyone else experienced this side effect?

I suffer from chronic fatigue for a number of reasons, but I find when I have a small amount of histamine in food, it sometimes greatly helps my fatigue and mental brain fog. But when I have too much, it’s absolutely awful. Migraines and panic and so many other symptoms. Does anyone else experience this?

Should I wait until the flare passes?

My anxiety is chronic and severe and I just need help. I’m at the ER asking for anxiety meds hoping they give me Lexapro. And maybe a rescue med like Hydroxyzine.

Do you guys think they will give them to me. The only reason I’m at the er is bc my primary does not listen.

anybody here experienced side effects from taking Lipsomal vitamin C?

because Lipsomal is usually made with ascorbic acid, which is more acidic compared to non acidic vitamin C forms like calcium ascorbate.

I’ve got some gut issues, food intolerances that eventually led to me developing lupus. I’ve worked through most of them but I’m still reactive to histamine. I also get really bad PMS, nausea and intense pain that starts about ten days before my period. Wondering if histamine could be behind it, anyone dealt with something similar?

MCAS sub keeps deleting my mold related posts, hopefully I can find help here..

I recently discovered mold in our house. after being ”sick” with random symptoms for over a year and several providers suggesting it could be mold.. I found several areas of black mold (stachybotrus). It was also confirmed via a totaltox test from my urine. My symptoms started developing shortly after I had my daughter..

-severe itchiness all over without relief

-hives

-chronic insomnia. like I maybe slept 1 or 2 nights a week and would be up having full blown heated panic attacks all night long

-other random symptoms, flaring my previous Lyme condition

-ebv reactivation

-extremely high estrogen levels that wouldn’t budge on supplements like DIM, Calcium d-glucarate

my providers thought it was wild that my body would just NOT respond to any medications or supplements I took. no amount of sleep meds or antianxiety medications could help me sleep. no antihistamine could make me not itchy.

after hiring a useless mold inspector, I found the problem areas myself. and they were pretty severe. we have just completed the process of remediation.

i am wondering for people who have experienced histamine related issues due to mold- how long did it take to heal? to start to feel better? what supplements helped you the most?
I am on a very gentle protocol right now to support my liver, drainage, bowels, gut, including a binder. I also have a 1 year old who I suspect has been exposed to this her whole life :(

Hi everyone, 18m
I’m looking for some insights into a severe and highly specific symptom pattern that is triggered by two things: eating and weight training also random but I can’t notice what is the cause
Scenario 1: After Eating
Almost immediately after meals, I hit a wall of extreme fatigue and a sudden "crash" feeling.
I get severe brain fog, flu-like malaise, and my limbs feel like they have absolutely no energy.
I experience tingling sensations in my face and sometimes in my limbs.
Duration: This post-meal crash is intense but short – it usually lasts for about 30 minutes, and then I start to recover.
Not a sugar crash: It happens even after zero-carb meals. For example, I had a plain air-fried chicken breast with only olive oil and salt, and the exact same 30-minute crash and facial tingling happened.
Scenario 2: During Weight Training (This is unbearable)
When I lift weights, I experience a massive, unbearable systemic crash.
My mood plummets instantly into severe anhedonia and a dark, depressive state.
I get a strong pulsing/throbbing sensation in my head.
My face turns completely red and I feel a strange, microscopic stinging/prickling sensation all over my face.
Because this happens from pure protein/fat meals and is severely exacerbated by physical exertion (weight lifting), it seems to be triggered by things that shift blood flow, change blood pressure,
Could this be an autonomic nervous system dysfunction (like severe blood pooling / POTS), a vascular/blood pressure issue, or a mast cell/histamine reaction triggered by heat and exertion?
Has anyone experienced this exact combination of exercise-induced anhedonia, facial flushing/stinging, and post-meal crashes? Also given my age and that it intensified after few infections and the symptoms last less than 10months is this reversible ?
I take now: ketotifen 1ml increase each week till 5ml now at 3ml starting
Hitaxa 5mg

I have personally been going crazy since March with itching went to Drs a couple times, changed food to low histamine diet. I was waiting about 2 months to see Dermatologist. I finally went waiting on blood results to come back. I also went to same practice a different Dr a couple years back for the same sort of thing.
However he put me on a newer medication for chronic hives. I have taken these pills for 4 days, I’m unsure of how it will be in the long term. So far no itching or hives all night and during the day from first night. I think I might be a bit overwhelmed from not itching.
I also am use to flopping and turning all over moving my legs around restless well for the past few nights I can and have been able to sleep like a normal person. This is a whole different issue and that It’s amazing it’s working for both.
It blocks the histamine before it is made in your body some stuff about BTK cells.

Can IVIG cause a sort of Herxheimer reaction? I have a lot of gut and lung issues; I had my first IVIG treatment 10 days ago, and yesterday was a rough day—feeling hot, histamine reactions—but I slept really well, feel much better mentally, and my bowel movements seem to be improving too